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In turn, lysosomal rupture induces both release of cathepsin enzymes which causes breakdown of the cell constitutive proteins, and efflux of the protons which causes decrease of the cytosolic pH thus enabling cathepsin-mediated uncontrolled proteolysis of the cell

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Contraindications: liver failure, pancreatitis, inborn disorders of fat metabolism, primary carnitine deficiency, carnitine palmitoyltransferase deficiency, carnitine translocase deficiency, porphyria, and pyruvate kinase deficiency (127)

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